Abstract
The modulation of insulin release from the isolated pancreas using normal rats rendered hyperglycemic by in vivo glucose infusion was studied. In 24 h and 48 h hyperglycemic rats, the increase in the amount of insulin released was reduced in response to glucose challenge, but was unchanged in relation to arginine challenge. In 48 h hyperglycemic rats insulin secretion after glucagon challenge was preserved. It was concluded that hyperglycemia itself makes the pancreatic B-cell selectively insensitive to glucose.
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