Abstract
In this study, mesoporous bioactive glass 77S was synthesized by sol-gel method using two different ionic and nonionic surfactants. Physical-chemical properties of synthesized Bioglass were studied using techniques include X-ray diffraction, scanning electron microscopy, nitrogen adsorption and Fourier transform infrared spectroscopy. The results showed that using nonionic and ionic surfactants increased specific surface area by 3 and 5 times, respectively. By determining the silicon release in three different temperatures, the activation energy values of Si-O-Si for sample with surface area of 161 and 94 m 2 /g were calculated 1/10 and 1/5 of control glass with surface area of 34 m 2 /g. The pH of sample was evaluated in solutions buffered with TRIS. pH analysis results suggested a direct relation between surface area and pH changes, the greatest increase in pH was observed in the sample with the highest surface area. Moreover, the in vitro bioactivity test was also conducted in simulated body fluid (SBF) and formation of apatite layer was evaluated by scanning electron microscopy and X-ray diffraction after a day.
Highlights
During the last decades, the bone diseases and trauma have significantly increased
Bone-bonding ability of bioactive glasses is attributed to the formation and growth of a hydroxyl carbonated apatite (HCA) layer, which its composition is similar to mineral phase of bone
The hydroxyl carbonated apatite (HCA) layer is formed on the surface of glasses when they are soaked in simulated body fluid (SBF) or implanted in vivo [7]
Summary
The bone diseases and trauma have significantly increased. The need of artificial replacement which can be used to repair or reconstruct damaged part has always been the driving force behind the discovery and design of new biomaterial. High biocompatibility, positive biological effects, as well as bonding and integrating with living bone have made bioactive glasses as one of the most interesting bone graft materials during recent years [4,5,6]. Bone-bonding ability of bioactive glasses is attributed to the formation and growth of a hydroxyl carbonated apatite (HCA) layer, which its composition is similar to mineral phase of bone. This similarity let bioactive glasses have strong interaction and integration with bone [52]. The hydroxyl carbonated apatite (HCA) layer is formed on the surface of glasses when they are soaked in simulated body fluid (SBF) or implanted in vivo [7]. An amorphous calcium phosphate layer develops within the silica-rich layer, and the HA layer crystallizes, producing a hydroxycabonate apatite (HCA) layer [8,9,33]
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