Abstract
Suramin exerts antitumour effects by interfering with the biological activity of several growth factors. It is also known that growth factors, including epidermal growth factor, play a primary role in the protection of gastric mucosa and promotion of ulcer healing. In the present study, the penetration of suramin into the stomach as well as the influence exerted by this drug on ethanol-induced gastric mucosal damage were investigated. Suramin was administered by the intraperitoneal route to male rats every other day for fourteen days. Animals were then used for: 1. Assessment of suramin levels in plasma and tissues 2. Histomorphometric evaluation of ethanol-induced gastric mucosal damage 3. Measurement of gastric acid secretion after pylorus ligation.
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