Effect of superior colliculus lesions on sensory unit responses in the intralaminar thalamus of the rat

Abstract

The effects of kainic acid lesions of the intermediate and deep layers of the superior colliculus on the sensory input to the intralaminar thalamus of the rat were determined. Ipsiversive circling and contralateral sensory neglect were consistently seen after lesion placement. Two to 7 days later, the intralaminar thalamus was systematically explored for extracellular mechanoreceptive unit responses to high threshold and low threshold stimuli. On the side ipsilateral to the lesion the number of responsive units was reduced by 51%. The loss was particularly marked for nociceptive units (80%), and low threshold and complex units with orofacial receptive fields (73%). This effect may involve a partial deafferentation of the intralaminar thalamus as well as altered excitatory thresholds of thalamic neurons. It is suggested that the functionally distinct direct tectothalamic projection as well as the indirect tecto-reticulo-thalamic pathway are implicated.