Abstract
To investigate the hypothesis that sulpiride potentiates stereotyped locomotion at an intermediate dose of amphetamine, rats were assigned to one of four treatment groups (n=7 per group): vehicle + saline; 20 mg/kg sulpiride + saline; vehicle + 3.5mg/kg amphetamine; 20 mg/kg sulpiride + 3.5 mg/kg amphetamine. An automated tracking system was used to record distance moved and sequences of movements between quadrants in a circular open-field. The results showed that amphetamine increased horizontal distance moved, and increased the number and proportion of thigmotaxic trips around the perimeter of the apparatus. Sulpiride reduced amphetamine-induced hyperactivity and the number of perimeter trips, but had no effect on the proportion and maximum run length of perimeter trips. Thus sulpiride reduces the hyperactivity produced by an intermediate dose of amphetamine, but does not appear to affect the stereotyped nature of locomotion under the drug.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
