Abstract
THE mechanism of action of numerous substances used as anti-inflammatory agents is not completely understood1,2. Recently it has been shown that potent blockers of protein synthesis such as actinomycin and puromycin are effective inhibitors of the inflammatory response3. In addition, it has been shown that hydrocortisone acetate might exert at least some of its anti-inflammatory action by interfering with a basic process of protein synthesis3,4. In the experiments reported here we tested the possible anti-inflammatory effect of compounds which are known to bind sulphydryl (SH) groups, because these groups are essential for the transfer reactions involved in the synthesis of proteins5–7. In addition, the anti-inflammatory activity of some commonly used drugs was tested in the presence of a compound carrying a sulphydryl group.
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