Effect of Suloctidil on Shortened Platelet Regeneration Time in Cardiovascular Patients

Abstract

Previous investigations based on the measurement of platelet regeneration time (PRT) rather than platelet survival time (PST) have suggested that this parameter is significantly reduced in patients bearing vascular prosthetic material and in a number of patients with occlusive vascular disease (1). Since it is well-known that shortened PST can be normalised by antiplatelet drugs, it seemed interesting to investigate whether the measurement of PRT could also detect this effect. Suloctidil (S), a new vasoactive agent, has been chosen for this study which was perforad in parallel double-blind conditions vs placebo. 32 patient. (24 males and 8 females) with either prosthetic heart valves, aortoiliac grafts or occlusive arterial disease were investigated [mean PRT t/2 value before treatment for the S group (n=16), 2.8·.1 days]. They were given S at a dose of 600 mg, daily during 3 to 4 weeks. The results obtained indicate that S treatment significantly increases shortened PRT t/2 values (mean PRT t/2 value after S treatment : 3.8 ± 0.2; p < .001). Placebo treatment had no effect in a similar group of patients (n=16; mean PRT t/2 value before treatment : 3.0±0.1 days; after treatment : 3.2±0.2 days). (1) R. Roncucci et al., Thromb. Res., accepted for publication.