Abstract
When 50 nmol of 14C-arachidonate was injected into the pulmonary circulation of isolated hamster lungs, the perfusion pressure was increased. This increase was not changed when sulfinpyrazone was infused into the pulmonary circulation at 20 mumol/l. Neither was the total amount of radioactivity in the effluent changed by sulfinpyrazone. The metabolites of arachidonic acid were analyzed from the nonrecirculating perfusion effluent, which was extracted with ethyl acetate first at neutral pH and then at pH 3.5. The only significant change in the metabolite formation was a small decrease in the amount of one metabolite extracted at neutral pH (obviously 12-hydroxy-5,8,10-heptadecatrienoic acid). The amounts of other metabolites, including 6-keto-PGF1 alpha, PGF2 alpha, PGE2 and TxB2 were unchanged. The present study indicates that the pulmonary metabolism of arachidonic acid is changed only slightly by sulfinpyrazone.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
