Abstract
The effect of sulfanilamide and sulfapyridine on some of the bacterial infections has been so striking that these drugs have been tried on many others, including some of the malarias, both of man and of animals. The results obtained have been of considerable interest, and not the less so because they have varied a great deal with the species. Coggeshall,1 for example, found that sulfanilamide was effective in eradicating Plasmodium knowlesi infection in monkeys, but was apparently without any action on Plasmodium inui in the same host. He suggested that the difference might be due to the much more rapid metabolism of the former species. This seems probable in view of the generally accepted idea that sulfanilamide is effective because oxidation products are formed from it which destroy catalase, and hence interfere with the metabolic activities of the cell. Since the malaria parasites are present in the blood stream they are presumably more exposed to this effect than if they were segregated somewhere in t...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
