Abstract
Objective:To investigate the influence of sufentanil on calcium-activated K+ channels(IKCa) in rat abdominal aortic smooth muscle cells,and to investigate its role in dilation of blood vessels.Methods:Rat abdominal aortic smooth muscle cells(AASMCs) were freshly obtained by enzymatic digestion.Whole-cell voltage-clamp technique was used to assess the effect of sufentanil(1×10-8,3×10-8,1×10-7mol/L) on IKCa.Results:Sufentanil significantly increased the amplitude of IKCa compared with the control group(P0.05 or P0.01).The effect of sufentanil was reversible and in a concentration-dependent manner.Conclusion:Sufentanil can promote the activation of KCa channel in rat AASMCs,which might be related to the vasodilatory effect of sufentanil observed in clinical practice.
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