Abstract
Objective:Study the efficacy of sublingual immunotherapy （SLIT） for monosensitized and polysensitized allergic rhinitis patients of different severity. Method:According to the results of intradermal experiments, 186 patients with AR who were treated with standardized dust mites SLIT for 2 years. These patients have been divided into mild monosensitized group and mild polysensitized group, moderate monosensitized group and moderate polysensitized group, severe monosensitized group and severe polysensitized group. Statistics and analysis of total nasal symptom score （TNSS）, total medication score （TMS） , visual analog scale （VAS） about before and after SLIT treatment. Result:Before SLIT treatment and after 2 years, the TNSS: Mild monosensitized group （5. 58±1. 68）（0. 58±0. 75）, mild polysensitized group（5. 34±1. 49）（0. 93±0. 75）;moderate monosensitized group （4. 68±1. 55）（0. 32±0. 63）, moderate polysensitized group（6. 26±1. 46）（0. 61±0. 67）,which have showed a statistically significant difference（P<0.05）,between the two groups have no significant difference （P>0.05）. Severe monosensitized group（6. 26±0. 73）（1. 16±1. 13）, severe polysensitized group（6. 49±1. 04）（1. 89±1. 07）, which have showed a statistically significant difference（P<0.05）, between the two groups have a statistically significant difference（P<0.05）. The VAS:Mild monosensitized group （6. 09±1. 23）（1. 52±1. 25）, mild polysensitized group（6. 21±0. 90）（1. 97±1. 18）,moderate monosensitized group（6. 12±0. 53）（1. 16±1. 03）, moderate polysensitized group（6. 65±1. 08）（1. 65±0. 98）,which have showed a statistically significant difference（P<0.05）,between the two groups have no significant difference （P>0.05）. Severe monosensitized group（6. 26±0. 73）（1. 16±1. 13）, severe polysensitized group（6. 49±1. 04）（1. 89±1. 07）, which have showed a statistically significant difference（P<0.05）, between the two groups have a statistically significant difference（P<0.05）. The TMS:These have showed a statistically significant difference（P<0.05）with same group,between all groups have no significant difference （P>0.05）. Conclusion:Dust mites under the SLIT are effective for monosensitized and polysensitized allergic patients. For patients with severe polysensitized , it is necessary to extend the treatment time （>2 years）.
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