Effect of Subantimicrobial Dose Doxycycline Treatment on Gingival Crevicular Fluid Levels of MMP-9 and MMP-13 in Periodontitis Stage 2, Grade B in Subjects with Type 2 Diabetes Mellitus.

Mai S Attia,Jazia A Alblowi,Francesca Santilli

doi:10.1155/2020/2807259

Mai S Attia, Jazia A Alblowi + Show 1 more

Open Access

https://doi.org/10.1155/2020/2807259

Copy DOI

Abstract

The aim of this study was to investigate the effect of using subantimicrobial dose doxycycline as an adjunct in periodontitis stage 2, grade B in subjects with type 2 diabetes mellitus. A total of thirty patients were divided into the following two groups with reference to periodontitis, type 2 diabetes mellitus, and administration of the doxycycline drug: Group I: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP only. Group II: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP and doxycycline 20 mg. The following clinical measurements were recorded at baseline (prior to scaling and root planning) and after one and three months postoperatively: GI, PI, and PD with a periodontal calibrated probe. The levels of both MMP-9 and MMP-13, from 60 GCF samples, were analyzed by ELISA. Patients treated with SRP and doxycycline 20 mg showed a significant reduction of PD, PI, GI, MMP-9, and MMP-13 than patients who received SRP only. Improvements in parameters clinically and biochemically were observed following the adjunctive use of doxycycline subantimicrobial dose therapy for the management of stage 2, grade B periodontitis patients with type 2 diabetes mellitus.

Highlights

Periodontitis is a progressive multifactorial condition with accumulation of plaque and calculus and change in the subgingival microbiome ecology
Patients were diagnosed with periodontitis stage 2, grade B according to Papapanou et.,al [2]
All patients have the criteria of stage 2, grade B periodontitis with T2DM

Summary

Introduction

Periodontitis is a progressive multifactorial condition with accumulation of plaque and calculus and change in the subgingival microbiome ecology. This leads to a slow but progressive destruction of the periodontium [1]. Papapanou et al [2] proposed a new and more specific periodontal disease classification. This classification involves four stages of periodontitis according to severity, complexity, extent, and distribution. In addition to the stages, three grades that reflect biological characteristics were established. This study targeted patients with stage 2, grade B periodontitis [2]

Objectives

Methods

Results

Discussion

Conclusion