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Abstract
The conversion of progesterone-4-14C by quartered mouse adrenal glands to 18-oxygenated steroids was studied in vitro following incubation with the inhibitor, 2- methyl-l,2-bis-(3-pyridyl)-l-propanone (Su- 4885). The conversion of progesterone to aldosterone and 18-hydroxycorticosterone was decreased to less than one half of the controls at concentrations of Su-4885 (5 × 10-6M) lower than that required for the equivalent inhibition of corticosterone formation. Aldosterone and 18-hydroxycorticosterone were identified by the mobilities of the labeled steroids and their derivatives and by the constancy of radioactivity in different chromatographic systems. (Endocrinology 78: 343, 1966)
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