Abstract
Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA model in Wistar rats was used. Thirty Wistar rats (both sexes, 60 days old) were distributed in five groups of 6 rats each: the control group, that received no intervention; a prophylactic group, that received oral administration of 25 mg·kg-1·day-1 of SrRan for 28 days before induction of OA; a group treated with 25 mg·kg-1·day-1 of SrRan for 28 days after OA induction; a group treated with 50 mg·kg-1·day-1 during 28 days after OA induction; and a group that received oral saline for 28 days after induction. The assessment of pain behavior was performed considering articular incapacitation (weight-bearing test), mechanical hyperalgesia (Randall Selitto test) and motor activity (rotarod test), on days 0, 7, 14, 21, and 28. This experiment did not yield a significant difference when comparing the group that received SrRan prophylactically with the groups treated with 25 or 50 mg·kg-1·day-1 and the group that received oral saline. Thus, SrRan did not provide analgesia in either treated rats or as a prophylactic drug with the tested doses. Higher doses should be tested further to achieve possible significant results.
Highlights
Advances in the understanding of the pathophysiology of osteoarthritis (OA), such as the influence of biochemical stress or abnormal intra-articular biomechanics, and the inflammatory pathways involved, have allowed for a considerable increase in therapeutic targets for the disease
These drugs, known as disease-modifying osteoarthritis drugs (DMOADs), present the properties of reversing, stabilizing, or at least delaying the course of OA
No difference was observed between groups PROF25 and SAL. These results showed that the animals that received Strontium ranelate (SrRan) prior to OA induction did not approach the healthy standard of the Control group, nor were they significantly different from those that received saline (Figure 1)
Summary
Advances in the understanding of the pathophysiology of osteoarthritis (OA), such as the influence of biochemical stress or abnormal intra-articular biomechanics, and the inflammatory pathways involved, have allowed for a considerable increase in therapeutic targets for the disease. Some medications have been associated with reduction of cartilaginous lesions and decreased subchondral bone remodeling, changing the progression of OA [1,2,3,4,5]. These drugs, known as disease-modifying osteoarthritis drugs (DMOADs), present the properties of reversing, stabilizing, or at least delaying the course of OA. The drug strontium ranelate has shown promising results in the prevention of fractures and treatment of osteoporosis in postmenopausal women [12,13,14], indicating its probable utility in the treatment in OA [2,15,16,17]
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Schedule a callMore From: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
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