Abstract
Antioxidant supplementation and physical exercise have been discussed as strategies to minimize neurodegeneration in Alzheimer’s disease (AD). We investigated the neuroprotective effects of strength exercise (StrEx) and green tea (GT) supplementation either combined or isolated on memory impairments induced by a β‐amyloid characterizing an AD‐like condition. Wistar male rats were submitted to 8 weeks of StrEx or GT supplementation or its combination. AD was induced by injection of Aβ (25–35) in the hippocampus. We evaluate object recognition (OR) and social recognition (SR) memory, and then hippocampus was removed for biochemical analysis. StrEx improved OR and SR memory. StrEx combined with GT improved OR memory and did not improve SR memory. GT alone decreased antioxidant capacity and improved acetylcholinesterase activity. Both strength exercise or green tea are effective against cognitive impairments resultant of β‐amyloid but benefits do not add up when the two interventions are associated.Support or Funding InformationNational Council for Scientific and Technological Development of Brazil
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