Abstract
Objective To compare the effect of storage autologous blood component transfusion versus storage autologous whole blood transfusion on the cellular immune function and hemorheology in the patients undergoing spinal surgery. Methods Forty patients of both sexes, aged 32-60 yr, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, undergoing elective multilevel spinal surgery, were divided into 2 groups (n=20 each) using a random number table: stored autologous whole blood transfusion group (group A) and stored autologous blood component transfusion group (group B). Before blood sampling (T0), immediately after blood sampling (T1) and at the end of surgery (T2), arterial blood samples were collected for determination of red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct), erythrocyte aggregation index (EAI) and erythrocyte rigidity index (ERI). Venous blood samples were collected at T0, T2 and on day 6 after surgery (T3), the distribution of T lymphocyte subsets (percentage of CD3+ , CD4+ and NK cells) was measured, and CD4+ /CD8+ ratio was calculated. Results Compared with the baseline at T0, the percentage of CD3+ , CD4+ and NK cells and CD4+ /CD8+ ratio were significantly decreased at T2, 3 in group A and at T2 in group B, and RBC, Hb and Hct were significantly decreased at T1, and EAI and ERI were decreased at T1, 2 in two groups (P 0.05). Conclusion The effect of storage autologous blood component transfusion on cellular immune function is mitigated than that of storage autologous blood transfusion and the effects on hemorheology are comparable in the patients undergoing spinal surgery. Key words: Blood transfusion, autologous; Erythrocytes; Immunity; Hemorheology
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