Effect of steroid pulses in severe BK virus allograft nephropathy with extensive interstitial inflammation.

Abstract

As there is no specific antiviral treatment currently available for BK polyomavirus associated nephropathy (BKVAN), its management relies on immunosuppression reduction in kidney transplant patients. Data on efficacy of steroid pulses in this indication are lacking. We performed a retrospective monocenter study on 64 patients diagnosed with biopsy-proven BKVAN. Patients within the "pulse group" (n = 37) received IV methylprednisolone 10mg/kg 3 days consecutively. In the "low dose" steroid group (n = 27), patients were continued oral prednisone 5mg daily. Mean follow up was 78 months in the steroid pulse group and 56 months in the low dose group (p=0.15). Mean eGFR values at diagnosis were comparable, as well as other demographic characteristics. Mean BK plasma viral load was higher in "pulse" than in "low dose" steroid group. Pulse group had higher inflammation and tubulitis (p <0.05). Graft loss reached 57% in the "pulse" group versus 41% in the "low dose" group, p=0.20. Rejection events were similar. No major adverse event was statistically associated with steroid pulse, including infections, cancer, and de novo diabetes. No significant differences were found in the evolution of both groups of patients, despite patients receiving "pulse" steroids were identified as the most severe sharing higher BK viral load and more frequent active lesions on histology.