EFFECT OF STERILIZATION USING GAMMA RADIATION ON THE PHYSICOCHEMICAL PROPERTIES OF GEL CONTAINING ALOE VERA POWDER

Arif Budiman

doi:10.22159/ijap.2021v13i4.41771

Abstract

Objective: This study aims to prepare sterile gel containing aloe vera (AV) powder and evaluate its physicochemical properties after sterilization by gamma radiation. Methods: The gel was prepared using carbomer as stabilizer, and sterilized by gamma radiation. The physical stability was evaluated including organoleptic, pH, viscosity and sterilization. Furthermore, malic acid concentration was determined as a marker compound contained in the gel. Results: The gel was successfully prepared containing 20% AV powder and 25% carbomer. The physical properties including organoleptic, pH and viscosity were not significantly changed after sterilization, and also stable even after 28 storage days. Meanwhile, malic acid concentration before and after sterilization were 47.2 mg/ml and 43.9 mg/ml, respectively. This showed the physicochemical properties were not significantly different after sterilization. Conclusion: Gamma radiation is suitable to sterilize gel containing AV powder.

Highlights

Hydrogel have been used in many pharmaceutical fields such as drug delivery systems, tissue engineering, and wound dressing [1]
This is due to its structural feature and permeability, which increased its use in various fields including ophthalmology and dentistry
Hydrogel is used as sterile formulation

Summary

Introduction

Hydrogel have been used in many pharmaceutical fields such as drug delivery systems, tissue engineering, and wound dressing [1]. The carbomer gel can be sterilized by several methods including gamma radiation [6]. This study evaluates the physicochemical properties of aloe vera (AV) powder gel after gamma ray sterilization. The effect of gamma radiation on physicochemical properties of gel containing AV powder including the sterility test, organoleptic, pH, viscosity and malic acid concentration was investigated.

Results

Conclusion