Abstract
Background:Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial.Aims:We examined the effect of statins on the mortality of bacteremia patients.Materials and Methods:Major databases were searched for the pertinent clinical trials.Results:Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin.Conclusions:There may be a potential role of statins in similar inflammatory and infective conditions.
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