Abstract
Aim. To investigate the effects of static magnetic field (SMF) on oxidant and antioxidant parameters of the cancerous and noncancerous human gastric tissues. Materials and Methods. Gastric tissues obtained from patients with gastric cancer were used in the study. SMF was created by using two static magnets. Before and after treatment with SMF, oxidant and antioxidant parameters were measured in the tissue samples. Results. In the cancerous tissue, superoxide dismutase (SOD) activity was found higher and malondialdehyde (MDA) level was found lower as compared with noncancerous tissue. SMF affects oxidant/antioxidant parameters differently in the cancerous and noncancerous tissues. In this regard, SMF causes increase in SOD activity and decrease in MDA level in the noncancerous tissue. However, it decreases SOD and glutathione peroxidase (GSH-Px) activities and increases MDA level and catalase (CAT) activity in the cancerous tissue. There were no differences between nitric oxide (NO) and nitric oxide synthase (NOS) parameters in or among the cancerous and noncancerous tissues. Conclusions. SMF accelerates peroxidation reactions possibly by suppressing SOD and GSH-Px enzymes in the cancerous gastric tissue. This event caused by SMF might play part in the death of cancer cells, which may be a good supportive vehicle for the cancer therapy.
Highlights
Cancer is one of the leading causes of death in the world
There were no significant differences in other parameters between the two groups
There is no clear consensus on the effects of static magnetic field (SMF) on human cancers [21]
Summary
Cancer is one of the leading causes of death in the world. Stomach cancer was the fourth most common cancer and the second highest cause of death from cancer worldwide. Most cancer therapies involve combinations of various therapy protocols. Some negative effects of chemotherapy and radiotherapy have been known obviously. Classical therapies can be effective against many types of cancer, but they have toxic potential for normal tissues as well. Because of this fact, high dose of chemotherapy and radiotherapy enough to kill cancer cells completely may be impossible without significant side effects. The use of nonionizing magnetic fields has been shown to have therapeutic potential and warrants further researches on whether it has a positive role in the therapy of certain forms of human cancer [4]
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