Abstract
The effect of starvation on adrenal cortical function was studied in 12 obese female subjects. Measurements of plasma and urine 17-hydroxycorticoids (17-OHCS) as Porter-Silber chromogens, urine 17-ketosteroids (17-KS), and increase in plasma 17-OHCS after ACTH infusion, were made before and after a 13-day period of starvation. Before starvation mean levels for plasma 17-OHCS at 8:00 pm, 8:00 am, and after ACTH, and urinary excretion of 17-OHCS and 17-KS were within the normal range. After 13 days' starvation, during which the average weight loss was 23 lb, the mean 24-hr urinary excretion of 17-OHCS and 17-KS was reduced by 27 and 47%, respectively. Both the evening and morning levels of plasma 17-OHCS became elevated after starvation, reaching values as high as 150 μg/100 ml (mean values: 8:00 pm, 52.4 μg/100 ml; 8:00 am, 61.9 μg/100 ml). Comparisons of the differences between 8:00 pm and 8:00 am plasma 17-OHCS and increases after ACTH stimulation, before and after starvation, revealed that no significan...
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