Effect of Staphylococcal alpha toxin on evoked potentials in the myenteric plexus-muscle preparation of the guinea pig taenia coli

Abstract

Nerve and smooth muscle responses, of the electrically stimulated taenia coli of the guinea pig, were differentiated by means of tetrodotoxin, atropine and MnCl 2. The nerve action potential was resistant to the action of staphylococcal alpha toxin. However, the toxin caused a progressive decrease of first the indirectly and then the directly evoked action potential of this smooth muscle.