Effect of spirulina (Spirulina platensis) and vitamin E on arsenic induced toxicity in Quail

Md Mahmudul Hasan,Most Fayza Khatun,Rakibul Islam,Sumon Sarkar,Md Anowarul Haque

doi:10.3329/ajmbr.v6i1.46483

Abstract

Chronic arsenic toxicity is a severe disease in men and animals which occurs severely in Bangladesh. Arsenic (As) contamination in ground water used in drinking is the major concern because arsenic is present in human and animal food chain. This work was done in quails with a view to observing the efficacy of spirulina (Spirulina platensis) and vitamin E for prevention of arsenic toxicity. 60 quails were used in this study and animals were divided into control group (T0), arsenic treated group (T1), arsenic plus spirulina treated group (T2) and arsenic plus vitamin E treated group (T3). Each group consists of 15 quails. Quails of T0 group were given normal feed and water and kept as control. Quails of T1, T2 and T3 were given 100 mg arsenic trioxide/L drinking water daily for 30 days. In addition to arsenic trioxide quails of group T2 and T3 were simultaneously fed with spirulina @ 1 gm/kg feed and vitamin E @ 400 mg /kg body weight up to 30 days respectively. Five quails from each group (T0, T1, T2 and T3) were sacrificed at 15 days interval in order to determine haematological parameters. Result showed that in group T1, body weight gain was minimum, whereas in group T2 and T3 the body weight gain in quails were better. Reduction of TEC and Hb values were observed in arsenic treated group T1. Whereas in rest groups the TEC and Hb values were comparatively higher than arsenic treated group. Noticeable change observed in liver and kindey of arsenic treated group in compare to the control group. Histopathological changes also observed in liver and kindey of arsenic treated group in compare to the control group. In conclusion, spirulina and vitamin E have significant effect on body weight, hematological and postmortem and histopathological changes. Asian J. Med. Biol. Res. March 2020, 6(1): 93-98

Highlights

Arsenic is one of the most sensitive environmental issue in Bangladesh even it is a major health concern in Asia
The experiment was conducted to determine the efficacy of spirulina and vitamin E on arsenic toxicity in quails
It was undertaken to observe the effects of spirulina and vitamin E on body weight, hematological, postmortem and histopathological parameters in arsenic fed quails

Summary

Introduction

Arsenic is one of the most sensitive environmental issue in Bangladesh even it is a major health concern in Asia. It creates a serious public health problem in developing countries. The inorganic forms of arsenic exhibit the highest toxicity level (FAO, 1983). Millions of people are being exposed to inorganic arsenic through consumption of contaminated drinking water and food (Silbergeld et al, 2008). Arsenic (As) is a metalloid that occurs in organic and inorganic forms in water and soil throughout the world especially in Bangladesh, India and several other countries of Southeast Asia (Bhatacharya et al, 2009). The safety limit of arsenic accepted by Bangladesh government is 0.05 mg/liter for drinking water (WHO, 1999).

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