Abstract
The aim of this study was to investigate the effect of Spirulina platensis extract on the number of spermatogenic cells of rats with excessive physical exercise. Excessive physical exercise was achieved through one hour of swimming for 35 days. Twenty male rats were divided into five groups i.e (1) C-, control group, (2) C+, a group was only given swimming, (3) T1, a group was given 300 mg/kg BW of Spirulina platensis and swimming, (4) T2, a group was given 600 mg/kg BW of Spirulina platensis and swimming, and (5) T3, a group was given 1200 mg/kg BW of Spirulina platensis and swimming. Spirulina platensis extract was given orally once a day before swimming. ANOVA test followed with Duncan test showed that the number of spermatogenic cells significantly different among treatments (p<0.05). Excessive physical exercise was able to influence on the male reproduction system by declined on the number of spermatogenic cells in seminiferous tubules of male rat. The conclusion of this study was dose of 1200 mg/kg BW of Spirulina platensis extract could maintain the number of spermatogenic cells of male rat after excessive physical exercise. Keywords : Rattus norvegicus, Spirulina platensis, excesive physical exercise, spermatogenic cells
Highlights
Physical exercise is needed by human and animal to maintain good health, as the result, it can prevent some risk on disease later
Analysis of variance test followed with Duncan test had been done to see significant differences between treatment after counting the number of spermatogenic cells in seminiferous tubules male rat
A group was only given swimming showed the declined of spermatogenic cells in seminiferous tubules male rat (Table 1, Figure 1)
Summary
Physical exercise is needed by human and animal to maintain good health, as the result, it can prevent some risk on disease later. Regular physical exercise gives good effect for body which can prevent and treat many chronic disease, such as coronary. Excessive physical exercise induce oxidative stress, included increasing of free radical levels in body. The free radicals formed primaly are Reactive Oxygen Species (De Lima, 2012). Reactive Oxygen Species (ROS) may attack polyunsatured fatty acids on biomembrane, leading a chain of peroxidation reaction, and alter the membrane structure. This reaction can be defined as lipid peroxidation. Lipid peroxidation produce hydrocarbon gases and malondialdehyde (MDA), which this product is the most frequently sign of increasing ROS (Banerjee et al, 2003; Hairrudin et al, 2012; De Lima et al, 2012)
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