Abstract
► The effects of Spirulina maxima (SM) on testis function of diabetic male rat. ► SM improved metabolic parameters and testosterone levels in diabetic male rat. ► SM restored damage in seminiferous tubule and Leydig cells in diabetic rat testis. ► SM increased steroidogenic genes expression and decreased stress gene expression. ► SM might be beneficial for recovery of testis function in diabetic rat. Spirulina maxima is a blue–green alga widely used for therapeutic and health supplements and foods. This study aimed to investigate the effect of S. maxima extracts (SME) on the spermatogenesis and steroidogenesis in streptozotocin (STZ)-induced diabetic rat testes. Adult male rats were divided into control, SME (200 mg/kg bw/day, 4 weeks), STZ (single injection of 50 mg/kg bw), STZ + SME (SME 200 mg/kg bw/day, 4 weeks after STZ 50 mg/kg bw), SME + STZ (STZ 50 mg/kg bw after SME 200 mg/kg bw/day for 2 weeks) and water + STZ (STZ 50 mg/kg bw after water feeding for 2 weeks) groups. SME intake for 4 weeks significantly increased the body and testis weights, metabolic parameters, normal seminiferous tubules, Leydig cell number, testosterone levels and steroidogenic enzymes mRNA in the STZ treated rat. SME intake for 2 weeks before STZ injection also mitigated diabetic testis dysfunction. SME might have a protective effect on diabetic rat testis.
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