Abstract
To evaluate the effect of sperm treatment with exogenous platelet-activating factor (PAF) on IUI clinical pregnancy rate. Prospective randomized study. Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. Fifty-two couples with unexplained infertility, candidates for IUI. Sperm treatment with an exogenous mixture of PAF (final concentration, 10(-7) mol/L) in sperm-washing medium, direct swim-up technique of sperm preparation, a maximum of six IUI cycles per couple with or without PAF treatment. Clinical pregnancy rate (pregnancies confirmed by ultrasonography per hundred cycles). The overall clinical pregnancy rate after a maximum of six IUI cycles was significantly higher when sperm was treated with PAF compared with the rate after the direct swim-up technique (23.07% vs. 7.92%). Treatment of sperm with exogenous PAF might improve the clinical outcome of IUI in cases of unexplained infertility.
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