Abstract
Food allergy (FA) is an increasingly prevalent global public health issue.1 Oral food challenge (OFC) is the criterion standard for FA diagnosis.2 OFC is also used to calculate the threshold dose that children can safely consume, providing important information for risk management of children with FA. Because OFC may sometimes cause serious reactions, such as fatal anaphylaxis,3 ensuring the safety and efficacy of the challenge is essential. Threshold-dose-distribution models created using clinical OFC study data provide valuable information regarding quantitative risk assessment (estimating the probability of allergic reactions)4; however, the reacting ingested dose, that is, the eliciting dose (ED), varies for each patient with FA.
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