Abstract
Management of diabetes melitus is still a global problem because satisfactory therapeutic treatments have not been found. This study aimed to explore the possibility of soyghurt Lactobacillus (L.) acidophilus as an alternative therapy to lower blood glucose levels through the administration of soyghurt L. acidohillus to alloxan-induced diabetic rats. This was experimental laboratory research with a pre- and post-test design and control group. It was found that administering soyghurt L. acidophilus had a significant influence, but a combination of soyghurt L. acidophilus and glibenclamide was the most effective in lowering the blood glucose levels of the diabetic rats (p < 0.05). The blood glucose levels were reduced due to the local and systemic effects of soyghurt L. acidophilus in reducing proinflammatory cytokines. This complemented the mechanism of action of glibenclamide which increases insulin secretion. We can conclude that a combination of soyghurt L. acidophilus and glycbenklamid results in the largest decrease in blood glucose levels.
 Keywords: blood glucose, diabetic rat, L. acidophillus, soyghurt
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