Abstract
The present study was conducted to evaluate the effect of soybean seeds administration alone or combined with either insulin or glibenclamide on serum lipid profiles in diabetic rats. Male Wister rats were induced diabetes by a single subcutaneous injection of alloxan 100 mg/kg.b.w.The rats randomly divided into six groups (eight rats in each group): The first group served as a control, the second group was administered soybean seed 400 mg/kg.b.w orally as suspension, the third group injected insulin 10 I.U/kg.b.w, subcutaneously, the fifth group administered glibenclamide 5 mg/kg.b.w. orally. Accompaniment of soybean seeds with either of insulin or glibenclamide given the fourth and sixth groups, using the same routes and doses in the individual groups. All treatments were once daily for two weeks. Soybean seeds treatment alone resulted in an improvement of body weight and decrease of triglyceride and total lipids levels. While treatment with insulin or glibenclamide as alone or combination with soybean seeds showed a significant reduction in the levels of total cholesterol, triglyceride, low density lipoprotein, and total lipids, beside a significant increase in both body weight and high density lipoprotein. Beneficial effects were seen when soybean seeds combined with either of insulin or glibenclamide treatment. These results indicate the usefulness of soybean seeds in the management of diabetes through the hypolipidemic effects of soybean seeds in diabetic rats.
Highlights
Diabetes mellitus is a chronic metabolic disorder caused by insulin deficiency, often combined with insulin resistance, and it is a major cause of disability and hospitalization and it results in significant financial burden [1]
Group 1: Diabetic control rats; Group 2: diabetic rats were treated with soybean seeds at a dose of 400 mg/kg.of body weight[12]; Group 3: diabetic rats were treated subcutaneously with insulin (Actrapid, Novo Nordisk, Denmark) at a dose of 10 I.U. /kg of body weight [13]; Group 5: diabetic rats were treated with glibenclamide (Medochemic LTD-Cyprus) at a dose of 5 mg tablet (5 mg /kg of body weight) [14], Group 4 and 6; diabetic rats were given soybean coadminstrated with insulin and glibenclamide, respectively at same routes and dose as in individual treatment
When rats treated with insulin as alone or when companied with soybean seeds resulted a significant increase in body weight with a reduction in levels of low density lipoprotein, and total lipids in both two weeks, with significant reduction of levels of cholesterol, triglyceride and increased level of high density lipoprotein in the second week only
Summary
Diabetes mellitus is a chronic metabolic disorder caused by insulin deficiency, often combined with insulin resistance, and it is a major cause of disability and hospitalization and it results in significant financial burden [1]. WHO indicates that diabetes mellitus is one of the major killers of humans in our time [2].Management of diabetes without any side effect is still a challenge to the medical system,this has led to an increasing demand for natural products with antidiabetic activity and fewer side effects [3]. Previous study indicates that protein of soybean decreased cholesterol level in rats consume a diet rich in cholesterol [6]. Soybean protein administration reduced cholesterol, triglyceride, and Low density lipoprotein levels in healthy persons [7] as well as in diabetic patients [8], similar effect was noticed in rats (٩).The present study was designed to investigate the effect of soybean seeds alone or in combination with insulin or glibenclamide as hypolipidimic agent in experimentally diabetic rats
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