EFFECT OF SOY NUTS ON INFLAMMATION, ENDOTHELIAL FUNCTION, GLUCOSE, AND INSULIN IN ADULTS WITH METABOLIC SYNDROME

Abstract

Metabolic Syndrome (MetS), a clustering of risk factors for CVD and T2DM, has been increasing in prevalence. Inflammation and endothelial dysfunction represent early phases in the pathophysiology of these chronic diseases. A paucity of studies have examined soy consumption with MetS. This randomized controlled crossover trial investigated a commercially available soy snack (soy nuts) in menopausal women and older men with MetS. The hypothesis was that the soy snack would significantly attenuate inflammatory biomarkers, improve endothelial function, and achieve better glucose and insulin control. 9 adults with MetS were assigned in random order to the snack interventions for 4 weeks each: soy nuts and a macronutrient‐matched control (cookies baked in‐house). Outcome measurements included RH‐PAT, blood samples, anthropometrics, and food records. Preliminary baseline characteristics include 3M and 6F, 55.3±4.9 years, BMI 31.5±3.4 kg/m2, and 3.7±0.7 of 5 MetS criteria. Current results show no significant differences between snack interventions, time, and order. Equol status, NO, ET‐1, IL‐10, and food records will also be analyzed. Collectively, the enrollment goal is 18 and statistical analysis at that time will better reveal effects of soy nuts on inflammation, endothelial function, glucose, and insulin in adults with MetS.Grant Funding Source : UC Davis Departmental Funds and Henry A. Jastro Research Award