Effect of source blur on digital breast tomosynthesis reconstruction.

Abstract

Most digital breast tomosynthesis (DBT) reconstruction methods neglect the blurring of the projection views caused by the finite size or motion of the x-ray focal spot. This paper studies the effect of source blur on the spatial resolution of reconstructed DBT using analytical calculation and simulation, and compares the influence of source blur over a range of blurred source sizes. Mathematically derived formulas describe the point spread function (PSF) of source blur on the detector plane as a function of the spatial locations of the finite-sized source and the object. By using the available technical parameters of some clinical DBT systems, we estimated the effective source sizes over a range of exposure time and DBT scan geometries. We used the CatSim simulation tool (GE Global Research, NY) to generate digital phantoms containing line pairs and beads at different locations and imaged with sources of four different sizes covering the range of potential source blur. By analyzing the relative contrasts of the test objects in the reconstructed images, we studied the effect of the source blur on the spatial resolution of DBT. Furthermore, we simulated a detector that rotated in synchrony with the source about the rotation center and calculated the spatial distribution of the blurring distance in the imaged volume to estimate its influence on source blur. Calculations demonstrate that the PSF is highly shift-variant, making it challenging to accurately implement during reconstruction. The results of the simulated phantoms demonstrated that a typical finite-sized focal spot (~0.3mm) will not affect the reconstructed image resolution if the x-ray tube is stationary during data acquisition. If the x-ray tube moves during exposure, the extra blur due to the source motion may degrade image resolution, depending on the effective size of the source along the direction of the motion. A detector that rotates in synchrony with the source does not reduce the influence of source blur substantially. This study demonstrates that the extra source blur due to the motion of the x-ray tube during image acquisition substantially degrades the reconstructed image resolution. This effect cannot be alleviated by rotating the detector in synchrony with the source. The simulation results suggest that there are potential benefits of modeling the source blur in image reconstruction for DBT systems using continuous-motion acquisition mode.