Effect of some Medical Plant Extracts and Chemicals on Hormones of Female Rats

Abstract

The study was carried out on 45 sexually mature female albino rats at the age of 7-8 weeks and weighing 160-180 ± 10 gm., nine treatments were used in this study, where five rats were isolated for control treatment (without infection). The remaining rats were injected (Subcutaneous) with Indian-made Alloxan, which was prepared at the time of injection at a dose of 100 mg/kg of body weight. The purpose of this study was to determine the effect of extracts of medical plants (Curcumin, Origanum majorana, and Vitex aguns-castus) at 50-100 mg/kg body weight and chemotherapy (metformin at 50 mg/kg body weight) on hormones. The results showed a significant increase in LH hormone in the T3, T4, T5, T7, and T9 treatments compared with the T2 treatment. A significant increase in FSH was observed in T3, T4, T5, T6, T7, and T9 treatments compared with T2 treatment. The results of the statistical analysis indicated a significant increase in progesterone in the T3, T5, T7, and T9 treatments compared with the T2 treatment. While T3, T5, and T9 treatments were significantly superior to T2, T4, T6, T7, and T8 treatments in terms of estrogen hormone. While a significant increase in cortisol was observed in the T2 treatment compared with the rest of the treatments. The aim of this study was to investigate the effect of aqueous extracts of Curcumin, Origanum majorana and Vitex aguns-castus leaves on the sex hormones of female rats. The results have shown that the aqueous extracts have a positive effect on hormones in female rats.