Abstract
Uptake of Ca by human myometrial mitochondria was inhibited by as low as 4 μM of diethyl stilbestrol (DES) in the medium, and 20 μM inhibited Ca uptake almost completely. Ethinyl estradiol and estradiol-17β also inhibited Ca uptake but the inhibition was smaller than DES and in the order DES > ethinyl estradiol > estradiol-17β. None of the agents had an effect on the mitochondrial ATPase in concentrations that inhibited Ca uptake. Progesterone did not affect either the Ca uptake or the ATPase activity. DES was also able to release Ca stored by mitochondria in concentrations that inhibited Ca uptake. Addition of supernatant fraction in the medium afforded protection from DES inhibition of Ca uptake. These findings together with those reported previously lend support to the argument for a role of mitochondria in contraction and relaxation of human myometrium.
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