Effect of some choline based deep eutectic solvents on volumetric and ultrasonic properties of gabapentin drug in water at T = (288.15 to 318.15) K

Abstract

A key part of the drug preparation process is the optimization of molecular interactions between drugs and solvents. Thermodynamic properties provides complete information on interactions and the selection of suitable solvents for various pharmaceutical processes. Especially, the investigation of antiepileptic drugs in aqueous solutions has been a subject of interest because they employ their effect by interaction with biological membranes. In this study, the density and speed of sound for the gabapentin (GBP) in aqueous deep eutectic solvents (DESs), (choline chloride/ethylene glycol (ChCl/EG), choline chloride/glycerol (ChCl/Gly), and choline chloride/urea (ChCl/U)) as novel category of green solvents were measured at temperature range 288.15 K to 318.15 K. The apparent molar volumes Vφ, apparent molar isobaric expansion Eφ0, Hepler’s constant and apparent molar isentropic compressibility κφ were calculated from the density and speed of sound data. Findings show that Vφ values are higher for binary systems compared to ternary systems. The order of Vφ values for aqueous DESs solutions are as follows: ChCl/EG > ChCl/U > ChCl/Gly. The standard partial molar volume Vφ0 and partial molar isentropic compressibility κφ0 were obtained by using the Redlich-Meyer equation. The obtained results for the Vφ0 quantity indicate a strong interaction between the GBP drug and the ChCl/Gly. Finally, using the results of Eφ0, it is understood that GBP has acted as a structure maker in the presence of all DESs.