Effect of Solanum Melongena Extract on the Xanthine Oxidase Inhibitory, Nitrite Scavenging, and Angiotensin I-Converting Enzyme Inhibitory Activities

Abstract

This research was to study effect of Solanum melongena extract on the xanthine oxidase (XO) inhibitory, nitrite scavenging (NC), and angiotensin I-converting enzyme (ACE) inhibitory activities. All the extracts inhibited the XO and ACE activities in a dose dependent manner. Especially, among various extracts, when 6.0 mg/mL of acetone extract was used, the maximum activity of XO inhibitory was obtained, 65.2%. On the other hand, in the case of methanol and ethanol extracts, they ranged of 61.5 to 62.4%. Acetone extract had a high phenolics and flavonoid concentration compared to other extraxts. Maximum NC activity using hot water extract at pH 1.2 was occurred, 68.7%. ACE inhibitory activity was significantly different among the various extracts at 6.0 mg/mL, values ranged from 35.26 to 56.7%. Especially, when 6.0 mg/mL of methanol and ethanol extracts were used, the highest ACE inhibitory activities were obtained, 57.3 and 56.7%, respectively. These results suggest that XO inhibitory, NC, and ACE inhibitory activities of S. melongena extract were strongly affected by extractant.