Abstract
Background: Sodium valproate is an antiepileptic drug primarily used to treat status epilepticus [SE]; however, its effect on cardiac function is unclear. This study aimed to examine the effect of 6 months of sodium valproate treatment on the cardiac index in new cases with status epilepticus. Methods: In this cross-sectional study, 30 cases with status epilepticus [18 boys and 12 girls] who were admitted to the Pediatric Intensive Care Unit of Hazrat-e Rasool Hospital were enrolled. Information on basic demographic and clinical data of all children, such as age, weight, gender, blood pressures, and underlying diseases, was recorded. Echocardiography and electrocardiogram [ECG] were performed for all cases before and after the treatment. Results: There were no abnormalities in ECG parameters [including PR, QRS, and QT intervals] after 6 months of treatment with sodium valproate. No significant differences were found in echocardiographic parameters, including blood pressure, pulmonary artery pressure [PAP], right ventricular [RV] size, diastolic dysfunction,], Tie index, end-diastolic volume [EDV], ejection fraction [EF], and TAPSE before and after study [p>0.05]. Conclusion: Administration of sodium valproate over 6 months is not associated with a serious adverse effect on heart function in children with status epilepticus.
Highlights
Epilepsy is a common chronic neurological disorder and a leading cause of mortality in Children
There was no significant difference in the mean of SBP and DBP between before and after the study
There was no significant difference in the mean of each quantitative echocardiographic parameter before and after the study
Summary
Epilepsy is a common chronic neurological disorder and a leading cause of mortality in Children. Status epilepticus (SE) is a condition in which a seizure lasts equal to or more than 30 minutes [2]. It is defined as a condition caused by the defects in factors responsible for seizure termination or from the initiation of mechanisms that lead to abnormally prolonged seizures [3]. Sodium valproate is an antiepileptic drug primarily used to treat status epilepticus [SE]; its effect on cardiac function is unclear. This study aimed to examine the effect of 6 months of sodium valproate treatment on the cardiac index in new cases with status epilepticus
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