Abstract
The effect of a bile acid, taurodeoxycholate (TDC) on the distribution and elimination of amaranth (AM), an anionic model drug, was studied in rats. Plasma concentration data of AM were analyzed for systemic clearance (CL s) and distribution volume at steady-state (Vd ss) after i.v. injection to the rats being infused with various concentrations of TDC. CL s and Vd ss were found to decrease in proportion to the TDC concentration of the infusate. This is in contrast to the effect of TDC on the pharmacokinetics of methylene blue (MB), an organic cation. It was suggested that ionic interaction between ionic drugs and endogenous ionic substances might affect the pharmacokinetics of the drugs substantially.
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