Year-end Sale % OFF 
Abstract
The effects of selenite on morphine hepatotoxicity and metabolism were examined. Pretreatment of male mice with sodium selenite (2 mg/kg, ip) 24 hr before morphine administration significantly protected them against the hepatotoxic effects of morphine as evidenced by decreased plasma alanine and aspartate transaminase values. This treatment inhibited the decrease in hepatic glutathione content that occurs in animals receiving hepatotoxic doses of morphine. Selenium pretreatment decreased the in vivo covalent bonding of morphine to hepatic proteins. Selenium also lowered the in vitro covalent bonding of morphine to hepatic microsomal proteins.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
