Abstract
By means of an automated single-lever shock-avoidance procedure, guinea pigs were conditioned to track absolute thresholds to a thermal noise stimulus. Threshold measurements were made under control conditions and 1–2 h following a single intraperitoneal injection of sodium salicylate. A temporary threshold-shift function was obtained for dose levels from 50 to 250 ms/ks of salicylate. Contrary to expectation, threshold shifts were not produced when salicylate doses below lethal amounts were cumulated over 4 days' time. Failure to demonstrate drug-induced TTS under chronic-dose conditions is discussed in terms of blood salicylate levels. Data are presented that suggest that the analgesic property of salicylate can account in part for the hearing-loss function obtained with avoidance-conditioning procedures. [Work supported in part by the National Institute of Neurological Diseases and Blindness, U. S. Department of Health, Education, and Welfare.]
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