Abstract
Effects of sodium orthovanadate on oocyte ovulation were examined during in vitro culture of Siberian sturgeon ovarian follicles from hibernating fish. It was shown that sodium orthovanadate stimulates ovulation of Siberian sturgeon oocytes in a dose-dependent manner. The stimulating or inhibitory effect of vanadate depends on the time of addition to the incubation medium. It was also shown that the stimulating effects of orthovanadate depend on the physiological status of hibernating females whose oocytes were isolated
Highlights
In recent decades аnthropogenic activities have led to the sturgeon population's decline [1]
It starts with a biochemistry cascade associated with signaling molecules such as cAMP, protein kinases, and phosphorylation subunits of G-proteins that leads to germinal vesicle breakdown (GVBD)
This study was aimed to demonstrate the effect of sodium orthovanadate on the ovulation of sturgeon oocytes in vitro depending on concentrations and time of addition
Summary
In recent decades аnthropogenic activities have led to the sturgeon population's decline [1]. Using a hormonal stimulation model in vitro of maturation and ovulation of sturgeon oocytes allows solving various fundamental and applied problems [3]. While the molecular mechanisms of maturation of fish oocytes were well understood [4,5], the ovulation process is still poorly understood. Maturation activity has been related to the action of steroid hormones on the oocytes, such as progesterone. It starts with a biochemistry cascade associated with signaling molecules such as cAMP, protein kinases, and phosphorylation subunits of G-proteins that leads to germinal vesicle breakdown (GVBD). Ovulation is a process following after GVBD
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