Effect of Sodium Lauryl Sulfate on Thymic Stromal Lymphopoietin mRNA and Protein Expression in Human Keratinocytes In Vitro.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a Th2/Th22 polarization. The prevalence of AD increased over the last few decades (DaVeiga, 2012). It is noted that the prevalence of AD is associated with the modern environment, especially with the industrialization development (Hoffjan and Epplen, 2005). Thymic stromal lymphopoietin (TSLP) has been found to have roles in AD (Soumelis et al., 2002). More recently, it was reported that injury in stratum corneum by topical sodium lauryl sulfate (SLS) could induce TSLP expression (Angelova-Fischer et al., 2010). Environmental factors may also induce TSLP expression, and TSLP is considered as a mediator linking environmental stimuli and host response (Takai, 2012).