Effect of Sodium Dodecylbenzenesulfonate on the Association Behavior of Promethazine Hydrochloride in Aqueous/Electrolyte Solutions at Different Temperatures

Abstract

The interaction between the amphiphilic phenothiazine drug promethazine hydrochloride (PMT) and an anionic surfactant sodium dodecylbenzenesulfonate has been investigated using the conductometric technique in the absence and presence of an inorganic salt (50 mmol·kg−1 NaCl) at five different compositions and temperatures. PMT is employed for the cure of allergic symptoms. Different physicochemical parameters such as critical micellar concentration (cmc), thermodynamic, and micellar composition are evaluated and discussed in detail using regular solution theory (RST). The addition of salt decreased the surface charge of micelles, lowering the cmc values of the amphiphile. The interaction parameter (β) is negative at all temperatures and compositions indicating attractive interactions. Due to the presence of NaCl in mixed systems the attractive interaction (β) was further increased (β values more negative). The negative values of Gibbs energy ( $$ \Delta G^{0}_{\text{m}} $$ ) of mixing revealed the stability of the solution. Owing to the presence of NaCl, the $$ \Delta G^{0}_{\text{m}} $$ values are found to be more negative suggesting that the driving force for interaction was significantly increased and micellization more thermodynamically favorable.