Abstract
The present study was carried out to investigate the effectiveness of sodium copper chlorophyllin (Cu-Chl-Na) as an in vivo lipid antioxidant by examining its effect on CCl4-induced hepatic injury. Rats received two i.p. injections of Cu-Chl-Na (50 or 100mg/kg) in and 2h prior to CCl4 administration (1 ml/kg, p.o.). It was found that in the pretreated rats, there was effective depression of both the CCl4-induced lipid peroxidation in hepatic microsomes and the CCl4-induced increase of lipid peroxides in whole liver at 0.5 and 24h after the dosing of CCl4, respectively. Cu-Chl-Na pretreatment also clearly inhibited the elevation of serum levels of glutamic oxaloacetic and glutamic pyruvic transaminases and isocitric dehydrogenase, and the increase in liver triglyceride level caused by CCl4. In addition, the hepatotoxin-induced decrease of hepatic tryptophan pyrrolase activity was substantially prevented in the rats pretreated with Cu-Chl-Na. Since the CCl4-induced peroxidation of liver lipids is generally accepted to be involved in the pathogenesis of its hepatotoxicity, the above in vivo antioxidative effect of Cu-Chl-Na is considered to play an important role in its protection of rats against the liver damage produced by CCl4.
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