Effect of sodium citrate on the rate of cholesterol esterification and on the formation of primary products of lipid peroxidation in human blood. Are these processes related?

Abstract

In vitro experiments show that sodium citrate in a final concentration of 130 mM induces a 4- to 5-fold increase in the activity of lecithin-cholesterol acyltransferase. A parallel determination of the blood content of primary products of lipid peroxidation reveals a 20–30% decrease in diene and triene conjugates and lipid hydroperoxides.