Effect of Sodium Carboxymethylcellulose on Post-Operative Peritoneal Adhesion Formation in Rabbits

Abstract

Thirty non-pregnant female albino rabbits of the blanc du Bouscat strain were selected for this study. Laparotomies were performed on the animals. Both uterine horns of each animal were transected, then repaired by end-to-end anastomosis. Before closing the abdomen, 1% sodium carboxymethylcellulose (SCMC), 7 ml/kg body weight, was instilled in 20 animals (study group) and dextran 70, 7 ml/kg body weight, was instilled in the remaining 10 animals (control group). Two weeks later, the animals were re-explored and adhesion formations were assessed. It was found that SCMC reduced adhesion formation in the treated animals more than dextran 70.