Effect of sodium amytal on the activity of muscle tissue phosphorylase during local ischemia

Abstract

The results clearly show that the phosphorylase activity of a muscle extract of the limbs in rabbits under-goes changes after application of a tourniquet in the waking and sleeping states, and that the changes, although in the same direction, are different in degree. This difference in the changes of enzyme activity in the experiments with and without the use of sodium amytal is proof that the functional state of the central nervous system plays an important part in the metabolic process taking place in the tissues of the part of the limb demarcated by the tourniquet.