Abstract
Treatment of acromegalic patients with somatostatin is a logical approach, since growth hormone (GH) cell adenomas possess somatostatin receptors and somatostatin is known to inhibit GH release. Because of short duration of its action, therapy with natural somatostatin is ineffective in patients with acromegaly. I has been shown recently that SMS 201-995, a long-acting somatostatin analog, reduces blood GH levels and ameliorates clinical signs and symptoms in GH excess. We report here morphologic findings in a pituitary GH cell adenoma removed by surgery from a 36-year-old acromegalic woman after 10 days of SMS 201-995 therapy. Treatment resulted in reduction of blood GH levels.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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