Abstract
number of cancers. Poison regression techniques will be used to determine if smoking has a significant effect on the SIRs. Results From these three datasets, 1185 MMR mutation carriers were identified, and smoking data was available for 1107 (93.4%). Subjects were dichotomized as ever smokers if they had ever smoked a cigarette a day for three or more months or never smokers. Based on this definition 580 (52.4%) were never smokers, and 527 (47.6%) were smokers. There were a total of34 urothelial cancers diagnosed in the entire study population, corresponding to ap revalence of 3.1 %. The mean age at diagnosis of urothelial cancer was 55.5 years (range 34-79 years). Urothelial cancer was the first cancer diagnosis in 10 cases (29.4%). Thirteen (38.2%) had one prior cancer, and 11(32.4%) had two or more prior cancers. Smoking data were available on 26 cases. Of those, 16 (61.5%) occurred in nonsmokers, and 10 (38.5%) occurred in smokers.
Highlights
Cigarette smoking is a well-described risk factor for a number of cancers and has been implicated as the most significant cause of urothelial cancer, conferring up to a 7-fold increased risk
Several studies have looked at the impact of gene-environment interaction on cancer risk in Lynch syndrome and have found that smoking may increase the risk for colorectal cancer
The interaction of smoking and mismatch repair (MMR) genotype has never been evaluated for urothelial cancer risk
Summary
Cigarette smoking is a well-described risk factor for a number of cancers and has been implicated as the most significant cause of urothelial cancer, conferring up to a 7-fold increased risk. Urothelial cancers are part of the spectrum of cancers associated with Lynch syndrome. Several studies have looked at the impact of gene-environment interaction on cancer risk in Lynch syndrome and have found that smoking may increase the risk for colorectal cancer. The interaction of smoking and mismatch repair (MMR) genotype has never been evaluated for urothelial cancer risk
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
