Abstract
The effect of S-methylfenitrothion on the activity of cholinesterase (ChE) of erythrocytes and plasma was studied as well as the time of its reactivation in rats after peroral administration of 2/3 to 1/100 of LD50. The degradation of S-methylfenitrothion in the organism of rats was evaluated according to the urinary excretion of its metabolite p-nitro-m-cresol. The S-methyl isomer was found to be a more potent inhibitor of cholinesterase than fenitrothion. A remarkable decrease of activity was found even after the administration of 1/100 of LD50. The reactivation of ChE after the administration of 2/3 LD50. took 6 weeks. The excretion was faster and the excreted amounts of p-nitro-m-cresol were significantly higher than they were after fenitrothion administration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International archives of occupational and environmental health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
