Abstract
ABSTRACT The effect of small doses of carrier iodide (127I′) upon the organic binding of radioactive iodine (131I) by the thyroid gland has been studied by performing 123 perchlorate discharge tests in normal persons and patients with abnormal thyroid function. In 86 tests, 100–2000 μg 127I′ was given with the iv 131I dose; the remaining 37 tests without carrier served as controls. In 60 of the 86 tests in which carrier iodide was administered, there was a positive perchlorate discharge of 131I from the thyroid gland, indicating that organic binding of iodine was impaired. In the 37 control tests, perchlorate discharge was observed only in 2 patients with untreated thyrotoxicosis. Although there was considerable individual variation, the minimum carrier dose of 127I′ required to cause demonstrable block of organic binding in normal persons appeared to be of the order of 750 μg, which resulted in a serum iodide level of 30–38 μg/1. However, a positive perchlorate discharge was observed in 1 of 3 TSH-treate...
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